Accucore Columns
Thermo Fisher — Accucore Columns
Products
Accucore Vanquish C18+ UHPLC Column
The Thermo Fisher™ Accucore™ Vanquish™ UHPLC Column is a next-generation ultra-high-performance liquid chromatography column engineered around a 1.5 µm solid core particle — combining the mechanical robustness of solid core technology with the chromatographic efficiency of a sub-2 µm particle. Designed for seamless integration with Thermo Fisher Vanquish UHPLC systems, these columns deliver sharper peaks, faster run times, and higher resolution for even the most demanding separations in pharmaceutical, environmental, food safety, and life science workflows. The C18+ reversed-phase chemistry provides excellent retention and selectivity across a broad range of polar and non-polar analytes, while the solid core architecture ensures exceptional efficiency even at elevated flow rates — directly translating to faster throughput without sacrificing data quality. Available in three column lengths (50, 100, and 150 mm × 2.1 mm ID), the Accucore Vanquish is the ideal upgrade for laboratories transitioning from larger-particle columns or seeking to maximize the performance of their Vanquish UHPLC investment. Subodh Trading Company is the authorized distributor of Thermo Fisher products across Maharashtra, India.
Accucore RP-MS HPLC Column
The Thermo Fisher™ Accucore™ RP-MS HPLC Column is a 2.6 µm solid core reversed-phase column engineered specifically for mass spectrometry detection. Built on an optimized alkyl chain length that provides exceptional silica surface coverage, the RP-MS phase delivers a significant reduction in non-hydrophobic interactions — resulting in highly efficient peaks with very low tailing, even for highly basic compounds such as amines and drug molecules. Offering slightly lower retention than C18 while matching its selectivity, the RP-MS phase is the ideal choice for laboratories running LC-MS/MS methods where fast, symmetric, low-tailing peaks are critical. Available in multiple lengths (30, 50, 100, 150 mm) and three internal diameters (2.1, 3.0, 4.6 mm), with Defender Guard column options for column protection. Subodh Trading Company is the authorized distributor of Thermo Fisher products across Maharashtra, India.
Accucore Biphenyl HPLC Column
The Thermo Fisher™ Accucore™ Biphenyl HPLC Column is a 2.6 µm solid core column offering complementary selectivity to C18 through a unique combination of hydrophobic and π-π (pi-pi) interactions. Where standard C18 columns resolve analytes purely on hydrophobicity, the Biphenyl phase adds aromatic ring-based selectivity — enabling resolution of structurally similar isomeric compounds that co-elute on C18, including drugs of abuse, steroids, benzodiazepines, opioids, and other aromatic or moderately polar analytes. The Accucore Biphenyl is 100% aqueous-compatible, operates at low backpressure without requiring a UHPLC system, and delivers exceptional lot-to-lot reproducibility with a rugged column lifetime suited for high-throughput forensic, clinical, and pharmaceutical matrices. Available in 50 mm and 100 mm × 2.1 mm formats, with Defender Guard drop-in cartridge options for column protection. Subodh Trading Company is the authorized distributor of Thermo Fisher products across Maharashtra, India.
Accucore C18 HPLC Column
The Thermo Fisher™ Accucore™ C18 HPLC Column is a 2.6 µm solid core reversed-phase column built on the industry-standard C18 chemistry — delivering the broadest analyte coverage, excellent hydrophobic retention, and robust reproducibility for routine and advanced HPLC and LC-MS/MS applications. The solid core particle architecture is designed to provide high chromatographic efficiency and excellent peak shape, making it a reliable workhorse column for pharmaceutical analysis, environmental monitoring, food safety, and general reversed-phase method development. Available in multiple lengths (30, 50, 100, 150 mm) and three internal diameters (1.0, 2.1, 3.0, 4.6 mm), with Defender Guard and UNIGUARD Drop-in Guard options for column protection. Subodh Trading Company is the authorized distributor of Thermo Fisher products across Maharashtra, India.
Accucore C8 HPLC Column
The Thermo Fisher™ Accucore™ C8 HPLC Column is a 2.6 µm solid core column engineered for analytes with medium hydrophobicity — offering lower hydrophobic retention than C18 while delivering complementary steric selectivity and excellent peak shapes. Built on a solid core particle platform with excellent bonded phase coverage, the Accucore C8 is designed to minimize secondary interactions, making it the preferred choice when a less hydrophobic stationary phase provides optimum retention for moderately polar analytes. With a USP L7 classification, pH range of 2–9, and 80 Å pore size, it is well-suited for pharmaceutical analysis, steroid and hormone profiling, and bioanalytical LC-MS/MS workflows. Available in multiple lengths (30–150 mm) and internal diameters (2.1, 3.0, 4.6 mm) with Defender Guard and UNIGUARD protection options. Subodh Trading Company is the authorized distributor of Thermo Fisher products across Maharashtra, India.
Accucore aQ HPLC Column
The Thermo Fisher™ Accucore™ aQ HPLC Column is a 2.6 µm solid core, polar endcapped C18 stationary phase engineered for the retention, resolution, and quantitative analysis of polar and highly hydrophilic analytes — including nucleosides, nucleotides, polar pharmaceuticals, and water-soluble compounds that are poorly retained on conventional C18 phases. The polar functional group used to endcap the Accucore aQ phase provides an additional controlled interaction mechanism, enabling polar compounds to be retained and resolved under highly aqueous mobile phase conditions. Critically, the polar endcapping makes the Accucore aQ fully usable in 100% aqueous mobile phases without risk of performance loss or stationary phase instability — a common limitation of conventional reversed-phase columns. Classified as USP L1, available in multiple lengths (30–150 mm) and internal diameters (2.1, 3.0, 4.6 mm), with Defender Guard and UNIGUARD protection options. Subodh Trading Company is the authorized distributor of Thermo Fisher products across Maharashtra, India.
Accucore Polar Premium HPLC Column
The Thermo Fisher™ Accucore™ Polar Premium HPLC Column is an exceptionally rugged amide-embedded C18 reversed-phase column offering high efficiency, a uniquely wide operating pH range (pH 1.5–10.5), and selectivity complementary to standard C18 phases. Built on a 2.6 µm solid core particle with a 150 Å pore size and classified as USP L60, the Polar Premium phase is specifically designed for polar embedded reversed-phase separations — providing retention and resolution of analytes that co-elute or are unresolved on conventional C18. The bonded phase is designed to be stable across an exceptionally wide pH range and will not undergo phase collapse in 100% aqueous mobile phases. Particularly well-suited for naturally derived complex mixtures, nutraceuticals, polar pharmaceutical compounds, and any application requiring alternative selectivity to C18 under simple isocratic or gradient conditions. Available in lengths from 50 to 250 mm and internal diameters of 2.1, 3.0, and 4.6 mm. Subodh Trading Company is the authorized distributor of Thermo Fisher products across Maharashtra, India.
Accucore Phenyl-Hexyl HPLC Column
Laboratories analyzing complex samples containing both aromatic and moderately polar analytes often face a fundamental selectivity gap — standard alkyl phases (C18, C8) cannot fully resolve aromatic compounds, while pure phenyl phases struggle with non-aromatic analytes. The Thermo Fisher™ Accucore™ Phenyl-Hexyl bridges this gap with a unique mixed-mode stationary phase combining a C6 alkyl chain with a phenyl ring — delivering classical reversed-phase retention alongside enhanced π-π interactions for aromatic selectivity, all on a 2.6 µm solid core particle platform. The reduced hydrophobicity of the Phenyl-Hexyl phase makes it ideal for the separation of very non-polar compounds, and its mixed-mode mechanism provides selectivity that neither conventional alkyl nor conventional phenyl phases can achieve alone. Classified USP L11 and stable across pH 2–8, it is well-suited for pharmaceutical, food safety, and veterinary residue analysis by LC-MS/MS. Subodh Trading Company is the authorized Thermo Fisher distributor across Maharashtra — serving laboratories in Pune, Aurangabad, Nagpur, Nashik, Kolhapur, Sangli, Solapur, and beyond. Contact: sales@subodhtrading.com
Accucore Phenyl-X HPLC Column
The Thermo Fisher™ Accucore™ Phenyl-X HPLC Column is a 2.6 µm solid core column built on a proprietary alkyl aromatic bonded phase — engineered to deliver unique reversed-phase shape selectivity that is fundamentally different from both standard C18 and conventional phenyl phases. The Phenyl-X exhibits particularly high aromatic selectivity, making it the preferred choice for the resolution of aromatic compounds, polycyclic molecules, and structurally similar analytes that are poorly differentiated on standard alkyl phases. Its advanced bonded phase design provides compatibility with highly aqueous mobile phases without risk of phase collapse, while delivering a robust, high-efficiency separation with very low column bleed. Classified as USP L11 with an 80 Å pore size and a pH range of 2–8, the Accucore Phenyl-X is well-suited for steroid and estrogen profiling, aromatic pharmaceutical impurity analysis, and any application requiring maximum aromatic shape selectivity. Available in lengths from 50 to 250 mm and internal diameters of 2.1, 3.0, and 4.6 mm.
Accucore PFP HPLC Column
The Thermo Fisher™ Accucore™ PFP (Pentafluorophenyl) HPLC Column is a 2.6 µm solid core column where the introduction of fluorine groups into the stationary phase causes significant changes in solute-stationary phase interactions — delivering alternative selectivity to C18, extra retention for halogenated species, and unique selectivity for non-halogenated polar compounds. PFP columns are well suited to the selective analysis of polar compounds containing hydroxyl, carboxyl, nitro, or other polar groups — particularly when these functional groups are located on an aromatic or rigid ring system. With USP L43 classification, pH range 2–8, and 80 Å pore size, the Accucore PFP is ideal for positional isomer separation, halogenated phenol analysis, fluorinated pharmaceutical characterization, and environmental contaminant monitoring. Available in multiple lengths (30–150 mm) and internal diameters (2.1, 3.0, 4.6 mm).
Accucore C30
Separating hydrophobic, long-chain structural isomers — carotenoids, steroids, and fat-soluble vitamins such as Vitamin K — demands a phase built for shape selectivity, not merely hydrophobicity. The Thermo Fisher™ Accucore™ C30 column delivers high shape selectivity for structurally related isomers through optimized bonding density of long C30 alkyl chains on a 2.6 µm Fused Core particle. This selectivity mechanism is distinct from that measured in conventional steric selectivity phase characterisation tests, making Accucore C30 effective where C18 phases fall short. Its excellent aqueous compatibility makes it a practical reversed-phase alternative to normal-phase columns for lipid analysis — engineered to remain stable even in highly aqueous mobile phases. Classified under USP L62, available as HPLC columns in 50–250 mm lengths across 2.1, 3.0, and 4.6 mm internal diameters, plus Defender Guard and Uniguard cartridge accessories.
Accucore HILIC
The Thermo Fisher™ Accucore™ HILIC column is a 2.6 µm solid core column engineered for enhanced retention of polar and hydrophilic analytes — delivering alternative selectivity to C18 without the need for ion-pair reagents or derivatization. Separation in HILIC mode occurs through two complementary mechanisms: a primary partitioning effect driven by the enriched water layer around the polar or charged substrate material, and a secondary mechanism involving interaction between the analyte and the active surface moiety. Analyte retention is governed by acidity/basicity, which determines hydrogen bonding, and polarizability, which determines dipole-dipole interactions. The highly organic mobile phases used with Accucore HILIC ensure efficient desolvation in ESI MS detection — translating directly to improved sensitivity in LC-MS workflows. Classified under USP L3 with a pore size of ~80 Å and a pH range of 2–8, available in lengths of 30–150 mm across 2.1, 3.0, and 4.6 mm internal diameters.
Accucore Urea-HILIC
The Thermo Fisher™ Accucore™ Urea-HILIC column is a 2.6 µm solid core column built on a bonded hydrophilic stationary phase — engineered to deliver unique selectivity compared to other HILIC phases with notably lower ion exchange activity. Unlike standard unbonded or charged HILIC phases, the Urea-HILIC bonded phase provides retention of a broad range of polar analytes using up to 20% aqueous mobile phase, making it suitable for applications where conventional HILIC phases introduce excessive ion exchange interference. The lower ion exchange activity of the Urea-HILIC phase translates to cleaner selectivity and more predictable retention for polar compound classes including analgesics, amino acids, and other hydrophilic analytes. With a pore size of ~80 Å and a pH operating range of ~2 to 8, Accucore Urea-HILIC is available in HPLC column lengths of 50–250 mm across 2.1, 3.0, and 4.6 mm internal diameters, plus Defender Guard and Uniguard cartridge accessories.
Accucore XL C18
The Thermo Fisher™ Accucore™ XL C18 column is a 4 µm solid core column engineered for optimum retention of non-polar compounds via a predominantly hydrophobic interaction mechanism — delivering high carbon loading and broad analyte coverage across a wide range of reversed-phase applications. The high carbon load of the Accucore XL C18 is designed to provide superior retention of non-polar analytes compared to fully porous particles of equivalent length, while the 4 µm Fused Core particle architecture is engineered to deliver higher plate counts and improved signal-to-noise ratios relative to conventional 5 µm fully porous C18 columns. With a pH operating range of 1 to 11, a pore size of ~80 Å, and USP L1 classification, Accucore XL C18 is well suited for pharmaceutical, environmental, and general reversed-phase HPLC applications requiring robust non-polar retention. Available in lengths of 50–250 mm across 2.1, 3.0, and 4.6 mm internal diameters, with Drop-in Guard accessories.
Accucore XL C8
The Thermo Fisher™ Accucore™ XL C8 column is a 4 µm solid core column engineered to deliver similar selectivity to C18 with lower retention — designed specifically for analytes with moderate hydrophobicity, or for applications where a less hydrophobic stationary phase provides optimum peak shape and resolution. Built on the same 4 µm Fused Core particle platform as the Accucore XL C18, the C8 phase is recommended when analytes are insufficiently retained on C8 alternatives or when stronger C18 retention leads to excessively long run times and poor peak shapes for moderately hydrophobic compounds. With a pH operating range of approximately 2 to 9 and a pore size of ~80 Å, Accucore XL C8 is classified under USP L7 and well suited for endocrine disruptor screening, moderately hydrophobic pharmaceutical compound analysis, and environmental applications. Available in lengths of 50–250 mm across 2.1, 3.0, and 4.6 mm internal diameters, with Drop-in Guard accessories.
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